Investigation of the mechanism of the reduction of anthracycline-induced cardiotoxicity by Qishen Huanwu Capsule based on network pharmacology

Background: Cancer patients who receive anthracycline-based chemotherapy regimens often discontinue due to cardiotoxicity. Preventing and reducing anthracycline-induced cardiotoxicity (ACT) is a hot topic in cardio-oncology research. Network pharmacology new discipline that integrates pharmacology, bioinformatics, systems biology. It can be used analyze the mechanism of action drugs body from holistic perspective by constructing “disease-gene-drug” network, providing method explore compounding mechanisms Chinese medicine. Based on network this study explored reduction anthracyclines Qishen Huanwu Capsule.